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Mixing Kratom with Other Prescription Drugs is Dangerous

Mixing Kratom with Other Prescription Drugs is Dangerous

Many Southeast Asian communities use Kratom as an alternative medicine. Its popularity in other continents has increased over the years. Kratom is used to treat anxiety disorders, opioid addiction and to relieve chronic pain. But, many countries lack laws that regulate Kratom use. Here is an insight into the pharmacology of Kratom and why it is dangerous to mix it with prescription drugs.

The Pharmacology of Kratom

The Food and Drug Administration (FDA) published a report in February 2018 which revealed that Kratom is an opioid. The agency identified over 20 alkaloids such as indole alkaloid mitragynine which is a kappa-opioid receptor agonist. It is more powerful than morphine. Scientific research shows that mitragynine acts on the delta and mu-opioid receptors, noradrenergic and serotonergic pathways. It stimulates the alpha-2 adrenergic receptors and blocks the 5-hydroxytryptamine 2A receptors.

Kratom’s Interaction with other Medications

Here are some interactions between Kratom and prescription drugs that can be fatal:

1. Psychedelics and Kratom

Psychedelics are a form of medication that causes psychedelic experiences. They are serotonin receptor agonists. Psychedelics include psilocybin, mescaline, and LSD. It is not wise to combine them with Kratom.

2. Stimulants and Kratom

Coffee and cocaine are the most popular stimulants worldwide. However, amphetamines and yohimbine are stimulant drugs. Kratom is a natural stimulant. So, you might get overstimulated if you combine it with other stimulants. It will cause serious side effects such as anxiety, agitation, excessive sweating, and heart palpitations.

A combination of Kratom and other stimulants can cause high blood pressure. You should observe your seizure threshold. Experienced users of Kratom products combine it with little coffee.

3. Depressants and Kratom

There are different types of depressants. They include anti-anxiety medications, tranquilizers, and benzodiazepines. The drugs work in the same way as opiates. You will experience severe sedation if you combine depressants with Kratom. It could result in respiratory depression. Avoid brewing kava since it is a mild depressant.

4. Selective Serotonin Reuptake Inhibitors (SSRIs) and Kratom

Doctors use SSRIs to treat severe depression. They are known as anti-depressants. Kratom interacts with the mu-receptors while SSRI interacts with serotonin receptors in your brain. At times, both receptors interact with one another in specific processes. Thus, Kratom and SSRIs might react and damage your brain.

5. Monoamine Oxidase Inhibitors (MAOIs) and Kratom                                                                          

Monoamine Oxidase Inhibitors breakdown monoamine compounds. They prevent monoamine oxidases from metabolizing food in your stomach. It is risky to combine Kratom with MAOIs as it might cause fatal side effects. Avoid foods that are rich in amino acid tyramine as they usually inhibit monoamine oxidases.

Don’t combine Kratom with bay bean, sea bean, Syrian rue, and passionflower since they are Monoamine Oxidase Inhibitors. Combining Kratom with herbs or foods with a high amino acid tyramine content will stimulate you beyond the standard threshold. You might experience mental block and anxiety disorders.

The Drug Enforcement Administration (DEA) doesn’t control Kratom use in the United States. Various states have different regulation which controls the use and possession of Kratom. You can take Kratom in the form of capsules or extracts. It is advisable to take small doses to relieve mild pain. Also, don’t mix Kratom with prescription drugs such as psychedelics, depressants and Monoamine Oxidase Inhibitors (MAOIs).

Kratom is indeed a powerful plant. When used properly it can bring you overall wellness.

Does Kratom Cure Addiction?

Does Kratom Cure Addiction?

Kratom is an herbaceous plant whose leave contains 7-α-hydroxy mitragynine and mitragynine. It is popular in South East Asia. Health facilities offer Kratom as a cure for different health conditions. You can consume it as pills, powder and an extract. Some states in the U.S. ban the use and sale of Kratom. In this post, we discuss whether Kratom is capable to cure addiction.

Case Presentation

Courtney True is a 41-year-old woman who grew up in Mississippi. She got addicted to opioids at a tender age of 14. The addictions started after a doctor gave Courtney a Percocet prescription for chronic migraines. She got hooked to OxyContin by the time she reached 24. Ten years later, True relocated to Maine and became a nurse. She got married and bore two children. The Maine nurse started using heroin after the Drug Enforcement Administration (DEA) traced illegal online pharmacies.

True tried to quit abusing heroin many times. She used various remedies for withdrawal symptoms including valerian root and Imodium A-D. The young mother found a Kratom thread in Reddit in December 2016. Then, she had refrained from taking heroin for two days. Courtney suffered from diarrhea, cold sweats, and stomach cramps. She didn’t know much about the different Kratom forms and strains. But True was willing to try Kratom cure for her opioid addiction.

She asked her husband, John Wolstenhulme, to take her to a smoke shop in Portland to buy Kratom capsules, extracts, and leaves. They cost her $100. Courtney swallowed several capsules when she got inside their family car. Her withdrawal symptoms faded within 20 minutes. She hasn’t taken heroin for the last 17 months.

Courtney takes several glasses of grapefruit-Kratom juice daily. She recently confessed that Kratom has saved her family. For instance, Jeff Wolstenhulme, True’s stepson used fentanyl while John used opioids for 20 years. They have refrained from taking narcotics for more than three months now. Also, Courtney urged her mother to take Kratom to treat irritable bowel syndrome.

Kratom’s Ability to Cure Opioid Addiction

About 11 percent of essential drugs are obtained from plants, according to the World Health Organization. Drug enforcement agencies such as the Food and Drug Administration (FDA) and the DEA have debated on whether Kratom is an opioid. Oliver Grundmann from the University Of Florida College Of Pharmacy has published several reviews on the chemical compounds and structure of Kratom.

Medical facilities have provided medication-assisted treatments and methadone to opioid addicts for long. Even so, methadone is a strong opioid which you can get addicted to. The FDA requires all rehabs to administer methadone in small quantities. Kratom evokes euphoria when you take it in moderate doses. Avoid using it for more than six months to avoid Kratom addiction. Prolonged use of the extract causes opioid craving. Physicians treat it with naloxone and buprenorphine.

Kratom cure is a powerful pain reliever and sedative. You can consume Kratom in different forms including capsule, extract, and pill. Some rehabilitation centers use it to treat opioid withdrawal symptoms. Kratom interacts with the opioid receptors in your brain hence reducing the urge to take drugs. It is advisable to take Kratom in small doses as it causes sedation when taken in large quantities. Despite being ruled out by FDA and DEA as having an opioid effect to its users, Kratom does have its share of positive effects. There are more ways in which you can use this plant as medicine. Read our guides at https://apexkratom.com to learn more.